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- Title
Antiamnestic Effects of Antibodies to Glutamate in Experimental Alzheimer's Disease.
- Authors
Gorbatov, V. Yu.; Trekova, N. A.; Fomina, V. G.; Davydova, T. V.
- Abstract
Experiments on rats showed that neurodegenerative brain damage caused by administration of neurotoxic fragment of β-amyloid protein Aβ in a dose of 2 μg into Meynert giant cell nucleus leads to long-term memory impairment in rats. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage restores learning capacity of the experimental animals in the conditioned passive avoidance paradigm.
- Publication
Bulletin of Experimental Biology & Medicine, 2010, Vol 150, Issue 1, p23
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-010-1058-1