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- Title
Serosal involvement in adult-onset Still’s disease: A multicentre and retrospective study.
- Authors
Yixuan Li; Ruru Guo; Wenjing Li; Jiaqi Feng; Yuyang Jin; Jia Li; Liangjing Lu; Xuebing Feng; Xiaoxiang Chen
- Abstract
Objectives: This study evaluated the characteristics of serosal involvement in adult-onset Still’s disease (AOSD). Methods: Patients meeting the Yamaguchi classification criteria were classified into AOSD with and without serosal involvement according to their manifestations and sonography/radiography. Clinical data was retrospectively reviewed from 102 patients with AOSD in two centres. Results: Forty-two patients (41.2%) had serosal involvement. The frequencies of pulmonary infiltrate and impaired liver function were significantly higher in patients with serosal involvement (p = .002 and p = .007, respectively), who also had a higher modified systemic score (p = .009). In addition, the percentages of CD3+ T cells (p < .001) and, especially, the CD8+ T cells (p = .004) were significantly increased in the peripheral blood of AOSD patients with serosal involvement. Notably, patients with serosal involvement were more likely to develop macrophage activation syndrome (p = .047) and a chronic pattern (p = .016) during the follow-up. Conclusions: Patients with serosal involvement demonstrated the more severe disease activity and different immune phenotypes; these patients were more likely to develop macrophage activation syndrome, and they may require more aggressive treatment at an early time to control their systemic inflammation.
- Subjects
STILL'S disease; MACROPHAGE activation syndrome; IMMUNE reconstitution inflammatory syndrome; T cells
- Publication
Modern Rheumatology, 2023, Vol 33, Issue 3, p579
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1093/mr/roac048