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- Title
Benefits and risks of haematopoietic stem cell transplantation for systemic sclerosis: A systematic review and meta-analysis.
- Authors
Kana Higashitani; Kaoru Takase-Minegishi; Ryusuke Yoshimi; Yohei Kirino; Naoki Hamada; Hideto Nagai; Maki Hagihara; Kenji Matsumoto; Ho Namkoong; Nobuyuki Horita; Hideaki Nakajima
- Abstract
Objectives: We aimed to evaluate the efficacy and safety of haematopoietic stem cell transplantation (HSCT) in patients with systemic sclerosis. Methods: A systematic literature review and meta-analysis were carried out. We compared survival outcomes using the Kaplan-Meier method with patient-level data between HSCT and intravenous pulse cyclophosphamide. Additionally, the incidence rate of treatment-related deaths with HSCT was pooled using a random-effect model. Results: Of the 2091 articles screened, 22 were included: 3 randomized controlled trials and 19 observational studies. HSCT studies showed significant improvement in the skin thickness score and lung function. Despite treatment-related deaths being higher in HSCT than in intravenous pulse cyclophosphamide, the Kaplan-Meier analysis showed a high survival rate of 2 years post-transplant (log-rank, P = 0.004). The pooled frequency of transplant-related death from 700 systemic sclerosis patients was 6.30% (95% confidence interval 4.21-8.38). However, the estimated frequency of treatment-related deaths has been reducing over the last decade. Conclusions: HSCT is an effective treatment for systemic sclerosis, but the optimal indications must be carefully determined by balancing the risks.
- Subjects
HEMATOPOIETIC stem cell transplantation; SYSTEMIC scleroderma; STEM cell transplantation
- Publication
Modern Rheumatology, 2023, Vol 33, Issue 2, p330
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1093/mr/roac026