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- Title
Differential Role of Serotonergic Projections Arising from the Dorsal and Median Raphe Nuclei in Locomotor Hyperactivity and Prepulse Inhibition.
- Authors
Kusljic, Snezana; Copolov, David L.; van den Buuse, Maarten
- Abstract
While an involvement of brain serotonin systems in schizophrenia has been suggested by many studies, the relative role of different serotonergic projections in the brain remains unclear. We therefore examined the effects of selective brain serotonin depletion on psychotropic drug-induced locomotor hyperactivity and prepulse inhibition, two animal models of aspects of schizophrenia. Pentobarbital-anesthetized (60 mg/kg, i.p.) male Sprague-Dawley rats were stereotaxically microinjected with 1 ml of a 5mg/ml solution of the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into either the dorsal or median raphe nucleus. At 2 weeks after the surgery, rats with dorsal raphe lesions did not show changes in psychotropic drug-induced locomotor hyperactivity, but displayed partial disruption of prepulse inhibition. In contrast, rats with median raphe lesions showed significant enhancement of phencyclidine-induced, but not amphetamine-induced locomotor hyperactivity and a marked disruption of prepulse inhibition. These results provide evidence for differential involvement of serotonergic projections in locomotor hyperactivity and prepulse inhibition. This study may help to explain the role of different serotonin projections in the brain in the pathophysiology of schizophrenia.
- Subjects
SCHIZOPHRENIA; SEROTONIN; PHENCYCLIDINE; AMPHETAMINES; IMMUNOCHEMISTRY
- Publication
Neuropsychopharmacology, 2003, Vol 28, Issue 12, p2138
- ISSN
0893-133X
- Publication type
Article
- DOI
10.1038/sj.npp.1300277