We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Vascular Adventitia: Its Role in the Arterial Injury Response.
- Authors
Havelka, George E.; Kibbe, Melina R.
- Abstract
The belief that the adventitia serves only a structural purpose has changed over the last decade. Studies have begun to elucidate the role the adventitia plays in the arterial response to injury. The adventitial fibroblast plays an integral part in the development of neointimal hyperplasia. Adiponectin, an adipokine produced from periadventitial adipose tissue, exhibits numerous vasoprotective properties. Stem cells arise, in part, from the adventitia, and stem cell recruitment into the adventitia from the vasa vasorum has been shown to be important in the development of neointimal hyperplasia. The exact role the vasa vasorum plays in neointimal growth is poorly understood and different studies endorse conflicting viewpoints. Thus, understanding the nuances of adventitial pathophysiology will allow us to better appreciate the mechanisms behind the pathology of neointimal hyperplasia. This review will summarize recent findings on the active role the adventitia plays toward the development of neointimal hyperplasia.
- Subjects
ARTERIAL injuries; FIBROBLASTS; MACROPHAGES; STEM cells; HYPERPLASIA; REACTIVE oxygen species; BLOOD vessels; CONNECTIVE tissues; NITRIC oxide; ADIPONECTIN; PHYSIOLOGY
- Publication
Vascular & Endovascular Surgery, 2011, Vol 45, Issue 5, p381
- ISSN
1538-5744
- Publication type
Article
- DOI
10.1177/1538574411407698