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- Title
NANOCARRIER DRUG DELIVERY INVOLVES TARGETING CENTRAL NERVOUS SYSTEM (CNS) DRUGS: A KINETIC STUDY.
- Authors
SHUKLA, S. K.; AHARWAL, R. P.; TRIPATHI, S. K.; PATHAK, S.; PATEL, B.; DUBEY, M.; PANDEY, A.
- Abstract
The development of Blood brain barrier (BBB) targeting technologies is a very active field of research and development. One goal is to develop chemically modified derivatives of central nervous system (CNS) drug (Alprazolam) chemically modified nanoparticulate of drugs, capable of crossing biological barriers, in particular the BBB. Nanocarrier drug delivery involves targeting CNS drugs enclosed in a particular PVP-44000 polymer. Drug nanoparticles have been shown to increase bioavailability and enhance drug exposure for oral and parenteral dosage forms. Nanoparticles of Alprazolam were prepared by nanoperception method. Polyvinylpyrrolidone (PVP) -44000 greatly enhanced the solubility of poorly water soluble drug, i.e. Alprazolam. Drug release follows zero order kinetics with Fickian diffusion.
- Subjects
CENTRAL nervous system; BLOOD-brain barrier; FICK'S laws of diffusion; NEURAL development; ORAL medication; DRUG bioavailability
- Publication
Oxidation Communications, 2021, Vol 44, Issue 3, p556
- ISSN
0209-4541
- Publication type
Article