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- Title
Antibody and T-Cell Responses against SARS-CoV-2 after Booster Vaccination in Patients on Dialysis: A Prospective Observational Study.
- Authors
Kawashima, Moe; Saito, Hiroaki; Nishiuchi, Takamitsu; Yoshimura, Hiroki; Wakui, Masatoshi; Tani, Yuta; Nishikawa, Yoshitaka; Omata, Fumiya; Takita, Morihito; Zhao, Tianchen; Yamamoto, Chika; Kobashi, Yurie; Kawamura, Takeshi; Sugiyama, Akira; Nakayama, Aya; Kaneko, Yudai; Sawano, Toyoaki; Shibuya, Kenji; Kazama, Junichiro; Shineha, Ryuzaburo
- Abstract
Intensive vaccination is recommended for populations more vulnerable to COVID-19 infection, although data regarding the built of immunity after vaccination for dialysis patients are lacking. This prospective, observational cohort study of maintenance hemodialysis patients examined IgG antibody levels against the SARS-CoV-2 spike (S1) protein, neutralizing activity, and interferon gamma levels after the third dose of the BNT162b2 (Pfizer–BioNTech) or mRNA-1273 (Moderna) vaccine. Humoral immunity was repeatedly measured for up to two months. The study includes 58 patients on hemodialysis. Median neutralizing antibodies reached a maximum at 56 and 9 days after booster vaccination with BNT162b2 and mRNA-1273, respectively. The median IgG antibody titer reached a maximum of 3104.38 and 7209.13 AU/mL after 16 days of booster dose, and cellular immunity was positive in 61.9% and 100% of patients with BNT162b2 and mRNA-1273 vaccination, respectively. By repeating the measurements over a period of two months, we clarified the chronological aspects of the acquisition of humoral immunity in dialysis patients after a booster COVID-19 vaccination; most dialysis patients acquired not only humoral immunity, but also cellular immunity against SARS-CoV-2. Future research should investigate the continued long-term dynamics of antibody titers and cellular immunity after the third or further vaccinations, evaluating the need for additional vaccinations for hemodialysis patients.
- Subjects
BOOSTER vaccines; ANTIBODY formation; HEMODIALYSIS patients; COVID-19; CELLULAR immunity
- Publication
Vaccines, 2023, Vol 11, Issue 2, p260
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines11020260