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- Title
The usefulness of immunofluorescent tests in pemphigus patients in clinical remission.
- Authors
David, M.; Weissman-Katzenelson, V.; Ben-Chetrit, A.; Hazaz, B.; Ingber, A.; Sandbank, M.
- Abstract
Direct and indirect immunofluorescent studies (DIF, IIF) were performed on 24 pemphigus vulgaris patients who were in a state of clinical remission. The tests were repeated after an interval of 6 months. All the patients were on maintenance therapy with oral prednisone. The DIP in eight patients showed negative results among whom seven remained negative. Six patients out of 24 showed weakly positive fluorescence and ten patients showed strong positive fluorescence. The IIF was negative in 17 patients and positive in seven patients who also showed positive DJF. During a follow-up period of 20 months, one of eight patients with negative DIF relapsed compared with two of six patients with weak positive DIF and five of 10 patients with strong DIF. Five patients with strong DIP for IgG also had C3, of whom three relapsed, compared with five of 19 patients who were negative for C3. Pour of seven patients with positive IIF relapsed compared with four of 17 with negative IIF. It is suggested that repeated DIP tests in pemphigus patients, who are in clinical remission, may serve as an indicator for the immunological activity and be of help in the management of these cases.
- Subjects
IMMUNOGLOBULIN G; PEMPHIGUS; DISEASE relapse; PREDNISONE; ORAL drug administration; IMMUNOFLUORESCENCE; IMMUNOPHARMACOLOGY
- Publication
British Journal of Dermatology, 1989, Vol 120, Issue 3, p391
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1989.tb04165.x