We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes.
- Authors
Yueyuan Zheng; Junjie Guo; Xu Li; Yubin Xie; Mingming Hou; Xuyang Fu; Shengkun Dai; Rucheng Diao; Yanyan Miao; Jian Ren
- Abstract
Eukaryotic cells may divide via the critical cellular process of cell division/mitosis, resulting in two daughter cells with the same genetic information. A large number of dedicated proteins are involved in this process and spatiotemporally assembled into three distinct super-complex structures/organelles, including the centro some/spindle pole body, kinetochore/centromere and cleavage furrow/mid body/bud neck, so as to precisely modulate the cell division/mitosis events of chromosome alignment, chromosome segregation and cytokinesis in an orderly fashion. In recent years, many efforts have been made to identify the protein components and architecture of these subcellular organelles, aiming to uncover the organelle assembly pathways, determine the molecular mechanisms underlying the organelle functions, and thereby provide new therapeutic strategies for a variety of diseases. However, the organelles are highly dynamic structures, making it difficult to identify the entire components. Here, we review the current knowledge of the identified protein components governing the organization and functioning of organelles, especially in human and yeast cells, and discuss the multi-localized protein components mediating the communication between organelles during cell division.
- Subjects
MITOSIS; CELL division; KARYOKINESIS; BIOSYNTHESIS; ORGANIC compounds
- Publication
Frontiers in Microbiology, 2014, Vol 5, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2014.00573