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- Title
Neonatal alloimmune thrombocytopenia due to an antibody against a labile component of human platelet antigen-3b (Bak<sup>b</sup>).
- Authors
Kataoka, S.; Kobayashi, H.; Chiba, K.; Nakamura, M.; Shinada, S.; Morita, S.; Lin, M.; Shibata, Y.
- Abstract
We report the second case of neonatal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-3b (Bakb) antibody. The infant was severely affected with intracranial haemorrhage. Most importantly, we were able to detect this antibody only by using fresh, unfixed platelets as antigen. This antibody was detectable neither by conventional mixed passive haemagglutination, platelet immunofluorescence test using fixed platelets, nor by monoclonal antigen immobilization of platelet antigen assay using solubilized platelets. We assume that this antibody reacts only with fresh platelets and that the antigen is a labile component of HPA-3b (Bakb).
- Subjects
THROMBOCYTOPENIA; BLOOD platelet disorders; NEWBORN infants; BLOOD platelets; ANTIGENS; IMMUNOGLOBULINS
- Publication
Transfusion Medicine, 2004, Vol 14, Issue 6, p419
- ISSN
0958-7578
- Publication type
Article
- DOI
10.1111/j.1365-3148.2004.00537.x