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- Title
Molecular cloning and characterization of a novel human Rab (Rab2B) gene.
- Authors
Ni, X.; Ma, Y.; Cheng, H.; Jiang, M.; Guo, L.; Ji, C.; Gu, S.; Cao, Y.; Xie, Y.; Mao, Y.
- Abstract
Rab proteins are small-molecular-weight guanosine triphosphatases (GTPases) that control vesicular traffic in eukaryotic cells. The small GTPase Rab2 is a resident of pre-Golgi intermediates and is required for protein transport from the endoplasmic reticulum to the Golgi complex. We identified a novel human Rab (Rab2B) gene that was 2312bp in length and encoded a protein of 216 amino acid residues. The protein shared high homology with mouse Rab2 (identity 83 %, similarity 91%). The expression pattern of the human Rab2B gene showed that there is a transcript in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta, whereas specific bands of the transcript could not be detected in heart, brain, spleen, testis, ovary, small intestine, and leukocyte. Overexpression has been observed in colon adenocarcinoma CX-1. The Rab2B gene consists of nine exons and eight introns and is mapped to chromosome 14ql1.1-14ql1.2 by bioinformatics analysis.
- Subjects
MOLECULAR cloning; GUANOSINE triphosphatase; EUKARYOTIC cells
- Publication
Journal of Human Genetics, 2002, Vol 47, Issue 10, p548
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380200083