We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines.
- Authors
Adams, Cameron; Jadi, Ramesh; Segovia-Chumbez, Bruno; Daag, Jedas; Ylade, Michelle; Medina, Freddy A.; Sharp, Tyler M.; Munoz-Jordan, Jorge L.; In-Kyu Yoon; Deen, Jacqueline; Lopez, Anna Lena; de Silva, Aravinda M.; Premkumar, Lakshmanane; Yoon, In-Kyu
- Abstract
Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically notable viruses such as the 4 dengue virus serotypes (DENV-1-4). Distinguishing DENVs from ZIKV using the established serologic assays widely used for monitoring DENV transmission is difficult because of antibody cross-reactivity between these closely related flaviviruses. We describe a modified and improved recombinant envelope domain III-based serologic assay for detecting ZIKV type-specific antibodies in regions with endemic DENV transmission. When the assay was used to measure ZIKV seroprevalence in 2017 among children 9-14 years of age living in a region of the Philippines with endemic DENV transmission, we observed a ZIKV seroprevalence of 18%. Investigators should consider using the ZIKV envelope domain III-based assay, which is simple and readily adaptable for use in standard clinical and public health laboratories, to assess ZIKV seroprevalence in areas with endemic DENV transmission.
- Subjects
PHILIPPINES; ZIKA virus; SEROPREVALENCE; DENGUE viruses; FLAVIVIRUSES; SEROTYPES; ANTIGEN-antibody reactions; RESEARCH; DENGUE; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; RESEARCH funding; VIRAL antibodies; EPIDEMIOLOGICAL research
- Publication
Emerging Infectious Diseases, 2021, Vol 27, Issue 12, p3073
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2712.211150