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- Title
SARS Vaccine Development.
- Authors
Shibo Jiang; Yuxian He; Shuwen Liu
- Abstract
Developing effective and safe vaccines is urgently needed to prevent infection by severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). The inactivated SARS-CoV vaccine may be the first one available for clinical use because it is easy to generate; however, safety is the main concern. The spike (S) protein of SARS-CoV is the major inducer of neutralizing antibodies, and the receptor-binding domain (RBD) in the SI subunit of S protein contains multiple conformational neutralizing epitopes. This suggests that recombinant proteins containing RBD and vectors encoding the RBD sequence can be used to develop safe and effective SARS vaccines.
- Subjects
SARS disease; VACCINES; INFECTION prevention; PROTEINS; IMMUNOGLOBULINS; CORONAVIRUS diseases; EPITOPES
- Publication
Emerging Infectious Diseases, 2005, Vol 11, Issue 7, p1016
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/1107.050219