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- Title
FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells.
- Authors
McInnes, N; Sadlon, T J; Brown, C Y; Pederson, S; Beyer, M; Schultze, J L; McColl, S; Goodall, G J; Barry, S C
- Abstract
The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target of FOXP3 repression, but that FOXP3 also induces two miRs, miR-7 and miR-155, which specifically target the 3′-UTR of SATB1 to further regulate its expression. We conclude that FOXP3-regulated miRs form part of the mechanism by which FOXP3 prevents the transformation of the healthy breast epithelium to a cancerous phenotype. Approaches aimed at restoring FOXP3 function and the miRs it regulates could help provide new approaches to target breast cancer.
- Subjects
NON-coding RNA; BREAST cancer; CANCER cells; TRANSCRIPTION factors; TUMOR suppressor genes; EPITHELIAL cells; GENE expression
- Publication
Oncogene, 2012, Vol 31, Issue 8, p1045
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/onc.2011.293