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- Title
Chorioamnionitis: a multiorgan disease of the fetus?
- Authors
Gantert, M.; Been, J. V.; Gavilanes, A. W. D.; Garnier, Y.; Zimmermann, L. J. I.; Kramer, B. W.
- Abstract
The bacterial infection of chorion and amnion is a common finding in premature delivery and is referred to as chorioamnionitis. As the mother rarely shows symptoms of a systemic inflammation, the course of chorioamnionitis is frequently asymptomatic and chronic. In contrast, the fetal inflammatory response syndrome represents a separate phenomenon, including umbilical inflammation and increased serum levels of proinflammatory cytokines in the fetus. Ascending maternal infections frequently lead to systemic fetal inflammatory reaction. Clinical studies have shown that antenatal exposure to inflammation puts the extremely immature neonates at a high risk for worsening pulmonary, neurological and other organ development. Interestingly, the presence of chorioamnionitis is associated with a lower rate of neonatal mortality in extremely immature newborns. In the following review, the pathogeneses of inflammation-associated perinatal morbidity are outlined. The concept of fetal multiorganic disease during intrauterine infection is introduced and discussed.
- Subjects
FETAL diseases; CHORION; AMNION; CYTOKINES; UMBILICAL cord abnormalities; NEONATAL infections
- Publication
Journal of Perinatology, 2010, Vol 30, pS21
- ISSN
0743-8346
- Publication type
Article
- DOI
10.1038/jp.2010.96