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- Title
Causal relationship of serum nutritional factors with osteoarthritis: a Mendelian randomization study.
- Authors
Qu, Zihao; Yang, Fangkun; Hong, Jianqiao; Wang, Wei; Li, Sihao; Jiang, Guangyao; Yan, Shigui
- Abstract
Objectives OA is the most common form of arthritis worldwide and has a major impact on the quality of life among the older population. This study aimed at determining the potential causal effects of several serum nutritional factors on OA. Methods A total of seven serum nutritional factors were identified from genome-wide association studies. Summary statistics for OA were obtained from UK Biobank (194 153 for women and 166 988 for men) and a large genome-wide association studies meta-analysis based on the European population (455 221, 393 873 and 403 124 for overall, hip and knee OA, respectively). Two-sample Mendelian randomization approach was used to estimate the causal association between the selected nutritional factors and the risk of OA. Results The Mendelian randomization analyses suggested that serum calcium levels were inversely associated with overall OA (95% CI, 0.595, 0.850), hip OA (95% CI, 0.352, 0.799) and knee OA (95% CI, 0.461, 0.901). Serum retinol levels were also inversely associated with hip OA (95% CI, 0.257, 0.778). Moreover, sex-specific associations were observed between serum calcium levels (95% CI, 0.936, 0.998), iron levels (95% CI, 1.000, 1.012), selenium levels (95% CI, 0.923, 0.999) and OA in women. Conclusion In this study, an inverse causal association between serum calcium levels and OA was established. Serum retinol levels were inversely associated with hip OA. In addition, we provide evidence for the causal effect of serum calcium, iron and selenium on the risk of OA in women.
- Subjects
UNITED Kingdom; BLOOD serum analysis; TISSUE banks; CONFIDENCE intervals; NUTRITIONAL assessment; NUTRITION; IRON; COMPARATIVE studies; RISK assessment; SEX distribution; OSTEOARTHRITIS; ATTRIBUTION (Social psychology); GENOMES; DESCRIPTIVE statistics; MOLECULAR epidemiology; CALCIUM; SELENIUM; DISEASE risk factors
- Publication
Rheumatology, 2021, Vol 60, Issue 5, p2383
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keaa622