We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Primary myocardial disease in scleroderma--a comprehensive review of the literature to inform the UK Systemic Sclerosis Study Group cardiac working group.
- Authors
Bissell, Lesley-Anne; Yusof, Md Yuzaiful Md; Buch, Maya H.
- Abstract
Cardiac disease is prevalent in SSc and associated with a poor prognosis. Differentiating primary myocardial disease (SSc-cardiomyopathy) from ischaemic heart disease is difficult and the disease phenotype most at risk is unclear. A comprehensive literature review was performed to inform the UK Systemic Sclerosis Study Group for cardiac disease tasked with producing a best practice pathway for the management of cardiac disease in SSc. This review describes the prevalence of SSc-cardiomyopathy, its associated greater mortality and various manifestations (e.g. heart failure, arrhythmias and diastolic dysfunction). The limited evidence suggests SSc-cardiomyopathy is associated with other poor prognostic indicators, including diffuse cutaneous disease, positive SSc-specific serology, black ethnicity, older age at disease onset, tendon friction rubs, abnormal nail-fold capillaroscopy and worse quality-of-life scores. Differentiating SSc-cardiomyopathy from ischaemic heart disease requires well-planned studies. Non-invasive investigative techniques are improving the understanding of its pathophysiological basis.
- Subjects
TREATMENT of cardiomyopathies; AGE distribution; AGE factors in disease; ARRHYTHMIA; BLACK people; CORONARY disease; CUTANEOUS manifestations of general diseases; DIFFERENTIAL diagnosis; HEART failure; MEDICAL databases; INFORMATION storage &; retrieval systems; MEDICAL information storage &; retrieval systems; MEDLINE; CARDIOMYOPATHIES; QUALITY of life; RACE; SYSTEMIC scleroderma; PHENOTYPES; SYSTEMATIC reviews; EVIDENCE-based medicine; DISEASE complications; PROGNOSIS
- Publication
Rheumatology, 2017, Vol 56, Issue 6, p882
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kew488