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- Title
Antidepressant Activity of Hydroalcoholic Extract of Prunus domestica.
- Authors
Agrawal, Aashruti; Joshi, Ankur; Malviya, Sapna; Kharia, Anil
- Abstract
The main aim present study was to evaluate the effect of Prunus domestica hydroalcoholic extract as well as its interaction with conventional anxiolytic and antidepressant drugs using tail suspension test and forced swim test (FST) and to evaluate the possible mechanisms involved in its actions. The fruit of Prunus domestica were collected and authenticated. The extract of Prunus domestica showed the significant antidepressant activity comparable to the standard drug. The oral administration of Prunus domestica extract at 100 mg/ kg and 200 mg/kg respectively as compared to the control treated group showed an antidepressant activity comparable to that of standard drug. The antidepressant effects of Prunus domestica extract seem to be mainly associated with the activation of dopamine system and possess potential anxiolytic and antidepressant activities.
- Subjects
PLUM; ANTIDEPRESSANTS; FRUIT extracts; TRANQUILIZING drugs; DOPAMINE; THERAPEUTICS
- Publication
International Journal of Pharmacy & Life Sciences, 2018, Vol 9, Issue 2, p58
- ISSN
0976-7126
- Publication type
Article