We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
SYNTHESIS, CHARACTERIZATION, AND ANTIMICROBIAL EVALUATION OF IMINE-LINKED BENZOTHIAZINE COMPOUNDS BY ULTRASOUND METHOD.
- Authors
Kole, S.; Shukla, S.; Nayak, G.; Mehta, P. D.
- Abstract
This work seeks to evaluate the antibacterial properties of the compounds and create imine-linked benzothiazine derivatives using a novel, eco-friendly ultrasonic technique. Escherichia coli and Staphylococcus aureus were utilized to assess the synthetic compounds, SBIa-e, for their antibacterial activity. All compounds were soluble in organic solvents but insoluble in water, with yields ranging from 68 to 77%. The molecules showed stretching vibrations corresponding to various functional groups. The presence of amine hydrogen (2.0, 7.0 ppm), aliphatic protons (2.6-4.3 ppm), imine hydrogen (8.0-8.5 ppm), and protons of the aromatic ring (6.8-7.9 ppm) was indicated by the 1HNMR spectra. Both the bacterial strains were all susceptible to the antibacterial action of the compounds, which showed dose-dependent effects. When the compounds were compared to gram-positive bacteria, it was discovered that the former had greater effectiveness than the latter. SBId had the lowest IC50 against Staphylococcus aureus (70.16 µg/mL) and Escherichia coli (49.19 µg/mL) among the drugs whose IC50 values were calculated.
- Subjects
BENZOTHIAZINE; GRAM-positive bacteria; ULTRASONIC imaging; STAPHYLOCOCCUS aureus; ESCHERICHIA coli; AROMATIC amines
- Publication
Rasayan Journal of Chemistry, 2024, Vol 17, Issue 2, p746
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2024.1728777