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- Title
RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury.
- Authors
Fischer, Julius C.; Bscheider, Michael; Eisenkolb, Gabriel; Chia-Ching Lin; Wintges, Alexander; Otten, Vera; Lindemans, Caroline A.; Heidegger, Simon; Rudelius, Martina; Monette, Sébastien; Rodriguez, Kori A. Porosnicu; Calafiore, Marco; Liebermann, Sophie; Chen Liu; Lienenklaus, Stefan; Weiss, Siegfried; Kalinke, Ulrich; Ruland, Jürgen; Peschel, Christian; Shono, Yusuke
- Abstract
The article discusses the use of RIG-I/MAVS and STING signaling, citing the molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) in tissue injury. It cites on the development graft-versus-host disease (GVHD) in mice used in laboratory research of allogeneic hematopoietic stem cell transplantation. The article also suggests that activation of either RIG-I/MAVS or STING pathways during the acute intestinal tissue injury.
- Subjects
INTERFERONS; TISSUE wounds; GRAFT versus host disease; HOMOGRAFTS; STEM cell transplantation
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 386, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aag2513