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- Title
Abundance of circulating preadipocyte factor 1 in early life.
- Authors
de Zegher F; Díaz M; Sebastiani G; Martín-Ancel A; Sánchez-Infantes D; López-Bermejo A; Ibáñez L; de Zegher, Francis; Díaz, Marta; Sebastiani, Giorgia; Martín-Ancel, Ana; Sánchez-Infantes, David; López-Bermejo, Abel; Ibáñez, Lourdes
- Abstract
<bold>Objective: </bold>Soluble preadipocyte factor 1 (Pref-1) inhibits adipocyte differentiation. We tested whether circulating levels of soluble Pref-1 are higher in smaller fetuses.<bold>Research Design and Methods: </bold>We performed longitudinal assessments of circulating Pref-1 in infants born appropriate for gestational age (AGA) or small for gestational age (SGA) and also in late-gestational women and in newborns on days 2 and 3.<bold>Results: </bold>At birth, Pref-1 levels were ~100-fold higher than in adults, being in SGA fetuses ~50% higher than in AGA fetuses. By age 4 months, Pref-1 had reached near-adult levels and the original AGA versus SGA difference had disappeared. Pref-1 levels were low in late-gestational women and were still elevated in newborns.<bold>Conclusions: </bold>Pref-1 is abundantly present in the fetus, is higher in SGA than in AGA fetuses, and is likely to be of fetal origin. We speculate that Pref-1 in early life contributes to variation in postnatal adipocyte numbers, in the subsequent expandability of adipose tissue, and thus in the susceptibility to diabetes in later life.
- Publication
Diabetes Care, 2012, Vol 35, Issue 4, p848
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc11-1990