We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Sex Differences in Children with Autism Spectrum Disorder Identified Within a High-Risk Infant Cohort.
- Authors
Zwaigenbaum, Lonnie; Bryson, Susan; Szatmari, Peter; Brian, Jessica; Smith, Isabel; Roberts, Wendy; Vaillancourt, Tracy; Roncadin, Caroline
- Abstract
Sex differences were examined in 3-year-olds with autism spectrum disorders (ASD) ascertained from a high-risk cohort, and high- and low-risk comparison groups. Participants included 319 high-risk siblings and 129 low-risk controls. Eighty-five siblings were diagnosed with ASD, including 57 of 176 boys (32.4 %) and 28 of 143 girls (19.6 %), implying a relative odds of ASD of 1.65 in boys versus girls. There were modest sex differences on cognitive and adaptive skills and ASD symptom severity at age 3, but differences between boys and girls with ASD mirrored those in the non-ASD groups. The lower than expected male-to-female ratio, and the relatively high cognitive level among diagnosed children, suggest that we have identified an unanticipated number of higher-functioning girls with ASD.
- Subjects
CANADA; AUTISM risk factors; ADAPTABILITY (Personality); ANALYSIS of covariance; ANALYSIS of variance; AUTISM; SIBLINGS; CHI-squared test; COGNITION; CONFIDENCE intervals; EPIDEMIOLOGY; MULTIVARIATE analysis; RESEARCH funding; SEX distribution; DATA analysis; DESCRIPTIVE statistics; CHILDREN
- Publication
Journal of Autism & Developmental Disorders, 2012, Vol 42, Issue 12, p2585
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-012-1515-y