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- Title
Lessons learned from site-specific sampling and biological half-life of IGFII and IIE(68-88) peptide: a case study.
- Authors
Muller Kobold, Anneke C.; de Haan, Jacco J.; Bokkers, Reinoud P.H.; Ruiter, Simeon J.S.; van den Heuvel, Marius C.; Lentjes, Eef G.W.M.; Touw, Daan J.; de Jong, Koert P.
- Abstract
This article presents a case study on non-islet cell tumor induced hypoglycemia (NICTH), a rare condition associated with mesenchymal tumors. The study focuses on a patient with metastatic solitary fibrous tumors (SFT) and severe hypoglycemic symptoms. The researchers measured levels of insulin-like growth factor (IGF)-II and IIE(68-88) peptide in various sampling sites, including the hepatic vein draining the largest SFT metastasis. They also measured these substances in peripheral venous blood samples taken at different timepoints after tumor resection to determine their half-life and correlate the levels with tumor size and clinical parameters. The findings provide insight into the contribution of liver metastases to hormone production and highlight the importance of site-specific sampling in understanding the metabolism of tumor cells. However, the study suggests that site-specific sampling may have limited value in identifying the dominant hormone-producing site in patients with SFT.
- Subjects
PEPTIDES; HEPATIC veins; RENAL veins; INSULIN-like growth factor-binding proteins; SOMATOMEDIN A
- Publication
Clinical Chemistry & Laboratory Medicine, 2024, Vol 62, Issue 7, pe155
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2023-1031