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- Title
A Theoretical Lower Bound for Selection on the Expression Levels of Proteins.
- Authors
Price, Morgan N.; Arkin, Adam P.
- Abstract
Weuse simplemodels of the costs and benefits ofmicrobial gene expression to show that changing a protein's expression away from its optimumby 2-fold should reduce fitness by at least 0:2 . P,whereP is the fraction the cell's protein that the gene accounts for. As microbial genes are usually expressed at above 5 parts permillion, and effective population sizes are likely to be above 106, this implies that 2-fold changes to gene expression levels are under strong selection, as Ne . s ⪢ 1, where Ne is the effective population size and s is the selection coefficient. Thus, most gene duplications should be selected against. On the other hand, we predict that for most genes, small changes in the expression will be effectively neutral.
- Subjects
GENE expression; MOLECULAR genetics; PROTEIN expression; PROTEIN genetics; MICROBIAL genes
- Publication
Genome Biology & Evolution, 2016, Vol 8, Issue 6, p1917
- ISSN
1759-6653
- Publication type
Article
- DOI
10.1093/gbe/evw126