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- Title
Neuroinflammation Mediators are Reduced in Sera of Parkinson's Disease Patients with Mild Cognitive Impairment.
- Authors
KIÇİK, Ani; TÜZÜN, Erdem; ERDOĞDU, Emel; BİLGİÇ, Başar; TÜFEKÇİOĞLU, Zeynep; ÖZTÜRK-IŞIK, Esin; HANAĞASI, Haşmet; GÜRVİT, Hakan
- Abstract
Introduction: Cognitive impairment is common in Parkinson's disease (PD) and PD patients with mild cognitive impairment (PD-MCI) are at increased risk of developing Parkinson's disease dementia (PDD). Reliable biomarkers are required for objective identification of cognitive decline in PD. In this pilot study, serum levels of well-known mediators of neuroinflammation were measured in PD patients with or without MCI to find out the involvement of neuroinflammation and microglial activation in PD-MCI. Methods: 36 PD-MCI, 25 PD patients with normal cognition (PD-NC) and 19 healthy controls were recruited. Serum levels of NLR family pyrin domain containing 1 (NLRP1), NLRP3, caspase-1, NF-kB, IL-1b and IL-18 were measured by ELISA and a panel of neuropsychological tests was administered. Results: PD-MCI patients showed significantly reduced levels of NFkB, IL-1b and IL-18, whereas NLRP1, NLRP3 and caspase-1 levels were comparable among PD-NC and PD-MCI patients. IL-18 levels were positively correlated with Addenbrooke's Cognitive Examination-Revised and Symbol Digit Modalities Test scores. Conclusion: Levels of several microglial activation mediators are reduced in PD-MCI patients inferring a protective role to certain inflammation factors against cognitive decline in PD.
- Subjects
COGNITIVE testing; ENZYME-linked immunosorbent assay; INFLAMMATORY mediators; INTERLEUKIN-1; INTERLEUKINS; NEUROPSYCHOLOGICAL tests; PARKINSON'S disease; DNA-binding proteins; PILOT projects; MILD cognitive impairment; CASPASES; SIGNAL peptides; DISEASE complications
- Publication
Archives of Neuropsychiatry / Nöropsikiyatri Arşivi, 2020, Vol 57, Issue 1, p15
- ISSN
1300-0667
- Publication type
Article
- DOI
10.29399/npa.23624