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- Title
A 12-month, Open Label, Multicenter Pilot Study Evaluating Fingolimod Treatment in terms of Patient Satisfaction in Relapsing Remitting Multiple Sclerosis Patients - FINE Trial.
- Authors
AKMAN DEMİR, Gülşen; TÜRKOĞLU, Recai; SAİP, Sabahattin; YÜCEYAR, Nur; EFENDİ, Hüsnü; TURAN, Ömer Faruk; AĞAN, Kadriye; TERZİ, Murat; BOZ, Cavit; TUNCER, Aslı; KOÇER, Belgin; KASAP, Mithat; ÇALIŞKAN, Zeynep
- Abstract
Introduction: To assess satisfaction and quality of life in patients with relapsing--remitting multiple sclerosis (RRMS) who were receiving fingolimod (0.5 mg/day) for 12 months as a second-line treatment after switching from injectable agents. Methods: Patients aged 18--65 years with RRMS who fulfilled the eligibility criteria were enrolled from 16 centers throughout Turkey. Treatment Satisfaction Questionnaire for Medication and 36-item Short-Form Health Survey were completed at baseline and four visits to assess patient satisfaction and quality of life. Results: Forty-two patients (62% male; mean age: 35.7±9.4 years) were eligible for inclusion. Patient satisfaction scores at the end of the study (44.7±9.9) were significantly higher than those at baseline [32.0±9.9; (p<0.001)]. The only significant increase in the quality of life survey was in the emotional aspect (p=0.019). There were 124 adverse events and none of the five serious adverse events noted was considered drug- related. Conclusion: Large-scale comparative studies performed with disease specific quality of life instruments will allow more information on this issue.
- Subjects
TURKEY; IMMUNOSUPPRESSIVE agents; AMINO alcohols; COMPARATIVE studies; HEALTH surveys; IMMUNOLOGICAL adjuvants; MEDICAL cooperation; MULTIPLE sclerosis; PATIENT satisfaction; QUALITY of life; QUESTIONNAIRES; RESEARCH; DISEASE relapse; PILOT projects; TREATMENT effectiveness; DESCRIPTIVE statistics
- Publication
Archives of Neuropsychiatry / Nöropsikiyatri Arşivi, 2019, Vol 56, Issue 4, p253
- ISSN
1300-0667
- Publication type
Article
- DOI
10.5152/npa.2017.20515