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- Title
Decreased Superoxide Dismutase Activity after ECT and Correlation between Higher Oxidant Levels and Poor Response to ECT in Depression.
- Authors
VıRıT, Osman; DALKILIÇ, Alican; BULUT, Mahmut; BÜLBÜL, Feridun; ALTINDA&Ğ, Abdurrahman; ARMUTÇU, Ferah; KOÇOĞLU, Esra; ÇITAK, Serhat; SAVA#x015E;, Haluk Asuman
- Abstract
Objective: The literature regarding effects of electroconvulsive therapy (ECT) on oxidative metabolism (OM) reports conflicting changes in oxidant and antioxidant status in animal studies. The goal of this first human study was to investigate the changes in oxidants and antioxidants in plasma of depressed patients after ECT. Methods: Fourteen unipolar and two bipolar patients were included in the study. The blood samples were obtained within one hour before the 1st and within one hour after the 7th ECT sessions. Oxidants malondialdehyde (MDA), nitric oxide (NO), and xanthine oxidase (XO) and antioxidant superoxide dismutase (SOD) were measured in the plasma. Results: Before the 1st and after the 7th ECT sessions, the Hamilton Depression Rating Scale (HDRS) scores were 32.63±9.54 and 16.50±7.22, respectively (t=7.92, df=15, p<0.001). After the 7th ECT, SOD values were significantly lower than pre-ECT SOD values (p<0.05, Z= -3,459). There were no significant difference between pre-and post-ECT values of MDA, NO, and XO (p>0.05). However, pre-ECT SOD values were significantly and positively correlated with pre-ECT HDRS scores (r=0.641, p=0.007). Conclusion: The decrease in antioxidant enzyme SOD after ECT may damage the neurons by increasing oxidative stress. Thus, possible benefits of antioxidant supplementation during ECT should be investigated. Additionally, higher pre-ECT oxidant levels may predict a poor response to ECT in depression. (Archives of Neuropsychiatry 2010; 47: 247-51
- Subjects
TURKEY; ELECTROCONVULSIVE therapy; DEPRESSED persons; OXIDIZING agents; SUPEROXIDE dismutase; MENTAL depression; MALONDIALDEHYDE; NITRIC oxide; XANTHINE oxidase; THERAPEUTICS; ACADEMIC medical centers; BLOOD testing; HAMILTON Depression Inventory; BIPOLAR disorder; STATISTICS; DATA analysis; OXIDATIVE stress; SEVERITY of illness index; DATA analysis software; DESCRIPTIVE statistics
- Publication
Archives of Neuropsychiatry / Nöropsikiyatri Arşivi, 2010, Vol 47, Issue 3, p247
- ISSN
1300-0667
- Publication type
Article
- DOI
10.4274/npa.247