We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Schizotypy, attention deficit hyperactivity disorder, and dopamine genes.
- Authors
ETTINGER, ULRICH; JOOBER, RIDHA; DE GUZMAN, ROSHERRIE; O'DRISCOLL, GILLIAN A.
- Abstract
Previous research has suggested that there may be overlap between schizophrenia and attention-deficit hyperactivity disorder (ADHD). The relationship between schizotypal personality traits, ADHD features and polymorphisms was evaluated in dopamine-related genes. Thirty-one healthy, Caucasian men completed the Rust Inventory of Schizotypal Cognitions (RISC) and the ADHD Self-Report Scale (ASRS). Catechol-O-methyltransferase (COMT) Val158Met, dopamine receptors of the D3 type (DRD3) Ser9Gly, DRD4 variable number of tandem repeats (VNTR), and SLC6A3 VNTR polymorphisms were analyzed. RISC score was correlated with ASRS score ( r = 0.54, P = 0.003). COMT Met homozygotes had higher ASRS scores than Val homozygotes ( P = 0.005). These findings are consistent with evidence of overlap between schizophrenia and ADHD and support an involvement of COMT genotype in ADHD features.
- Subjects
ATTENTION-deficit hyperactivity disorder; SCHIZOTYPAL personality disorder; METHYLTRANSFERASES; CATECHOLAMINES; GENETIC polymorphisms; DOPAMINE; CAUCASIAN race
- Publication
Psychiatry & Clinical Neurosciences, 2006, Vol 60, Issue 6, p764
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/j.1440-1819.2006.01594.x