We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Off-label use of dalbavancin in children: a case series.
- Authors
Gamell, Anna; Velasco-Arnaiz, Eneritz; López-Ramos, Maria Goretti; Ríos-Barnés, María; Simó-Nebot, Sílvia; Fumadó, Victoria; Noguera-Julián, Antoni; Fortuny, Clàudia
- Abstract
Introduction Dalbavancin is an antibiotic active against most Gram-positive bacteria approved for acute bacterial skin and skin structure infections (ABSSSI). Owing to its long half-life, it is being increasingly used for other indications. Patients and methods We present a case series of children and adolescents treated with dalbavancin for osteoarticular, catheter-related and other non-ABSSSI infections. Results Dalbavancin was prescribed to 15 patients. Six (40%) were female and median age at prescription was 11.9 (IQR 1.3–18.0) years. Most of them (12/15) had significant comorbidities. Patients presented mainly with deep surgical site infections, osteoarticular infections and central-line-associated bloodstream infections. The most common isolate was Staphylococcus aureus followed by Staphylococcus epidermidis. Major reasons to prescribe dalbavancin were to ensure compliance and patients' convenience. Two patients discontinued the drug due to adverse events possibly related to it. The rest of the patients completed the treatment with dalbavancin, with a median duration of 56 days (IQR 17.5, 115.5). All achieved complete resolution and present no relapse after a median follow-up of 9.9 months (IQR 4.8, 16.6). Conclusions Dalbavancin was a safe, effective and convenient alternative in selected paediatric patients with complicated non-ABSSSI infections caused by Gram-positive bacteria.
- Subjects
PATIENT compliance; CHILD patients; SURGICAL site infections; OFF-label use (Drugs); STAPHYLOCOCCUS epidermidis
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2024, Vol 79, Issue 8, p2062
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkae212