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- Title
Plasma metabolomic analysis indicates flavonoids and sorbic acid are associated with incident diabetes: A nested case-control study among Women's Interagency HIV Study participants.
- Authors
Yu, Elaine A.; Alemán, José O.; Hoover, Donald R.; Shi, Qiuhu; Verano, Michael; Anastos, Kathryn; Tien, Phyllis C.; Sharma, Anjali; Kardashian, Ani; Cohen, Mardge H.; Golub, Elizabeth T.; Michel, Katherine G.; Gustafson, Deborah R.; Glesby, Marshall J.
- Abstract
Introduction: Lifestyle improvements are key modifiable risk factors for Type 2 diabetes mellitus (DM) however specific influences of biologically active dietary metabolites remain unclear. Our objective was to compare non-targeted plasma metabolomic profiles of women with versus without confirmed incident DM. We focused on three lipid classes (fatty acyls, prenol lipids, polyketides). Materials and methods: Fifty DM cases and 100 individually matched control participants (80% with human immunodeficiency virus [HIV]) were enrolled in a case-control study nested within the Women's Interagency HIV Study. Stored blood samples (1–2 years prior to DM diagnosis among cases; at the corresponding timepoint among matched controls) were assayed in triplicate for metabolomics. Time-of-flight liquid chromatography mass spectrometry with dual electrospray ionization modes was utilized. We considered 743 metabolomic features in a two-stage feature selection approach with conditional logistic regression models that accounted for matching strata. Results: Seven features differed by DM case status (all false discovery rate-adjusted q<0.05). Three flavonoids (two flavanones, one isoflavone) were respectively associated with lower odds of DM (all q<0.05), and sorbic acid was associated with greater odds of DM (all q<0.05). Conclusion: Flavonoids were associated with lower odds of incident DM while sorbic acid was associated with greater odds of incident DM.
- Subjects
TENOFOVIR; LIQUID chromatography-mass spectrometry; ELECTROSPRAY ionization mass spectrometry; HIV; METABOLOMICS; TYPE 2 diabetes; FLAVONOIDS
- Publication
PLoS ONE, 2022, Vol 17, Issue 7, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0271207