We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.
- Authors
Siland, J. E.; Geelhoed, B.; Roselli, C.; Wang, B.; Lin, H. J.; Weiss, S.; Trompet, S.; van den Berg, M. E.; Soliman, E. Z.; Chen, L. Y.; Ford, I.; Jukema, J. W.; Macfarlane, P. W.; Kornej, J.; Lin, H.; Lunetta, K. L.; Kavousi, M.; Kors, J. A.; Ikram, M. A.; Guo, X.
- Abstract
Background: Both elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped causal association between genetically-determined resting heart rate and incident AF is limited. We investigated potential directional changes of the causal association between genetically-determined resting heart rate and incident AF. Method and results: Seven cohorts of the AFGen consortium contributed data to this meta-analysis. All participants were of European ancestry with known AF status, genotype information, and a heart rate measurement from a baseline electrocardiogram (ECG). Three strata of instrumental variable-free resting heart rate were used to assess possible non-linear associations between genetically-determined resting heart rate and the logarithm of the incident AF hazard rate: <65; 65–75; and >75 beats per minute (bpm). Mendelian randomization analyses using a weighted resting heart rate polygenic risk score were performed for each stratum. We studied 38,981 individuals (mean age 59±10 years, 54% women) with a mean resting heart rate of 67±11 bpm. During a mean follow-up of 13±5 years, 4,779 (12%) individuals developed AF. A U-shaped association between the resting heart rate and the incident AF-hazard ratio was observed. Genetically-determined resting heart rate was inversely associated with incident AF for instrumental variable-free resting heart rates below 65 bpm (hazard ratio for genetically-determined resting heart rate, 0.96; 95% confidence interval, 0.94–0.99; p = 0.01). Genetically-determined resting heart rate was not associated with incident AF in the other two strata. Conclusions: For resting heart rates below 65 bpm, our results support an inverse causal association between genetically-determined resting heart rate and incident AF.
- Subjects
ATRIAL fibrillation; HEART beat; HEART beat measurement; DISEASE risk factors; HELLP syndrome; MONOGENIC &; polygenic inheritance (Genetics)
- Publication
PLoS ONE, 2022, Vol 17, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0268768