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- Title
The Usefulness of the Combination of D-Dimer and Soluble Fibrin Monomer Complex for Diagnosis of Venous Thromboembolism in Psychiatric Practice: A Prospective Study.
- Authors
Takeshima, Masahiro; Ishikawa, Hiroyasu; Ogasawara, Masaya; Komatsu, Munehiro; Fujiwara, Dai; Itoh, Yu; Wada, Yuki; Omori, Yuki; Ohta, Hidenobu; Mishima, Kazuo
- Abstract
<bold>Purpose: </bold>D-dimer has the advantage of excluding venous thromboembolism (VTE) due to its high sensitivity but is disadvantageous for diagnosing VTE due to its low specificity. A method to increase the usefulness of D-dimer in the diagnosis of VTE is warranted. This study aimed to investigate the usefulness of the combination of D-dimer and soluble fibrin monomer complex (SFMC), which has been suggested as a new candidate marker for VTE, in VTE diagnosis.<bold>Patients and Methods: </bold>This prospective study in 109 subjects was performed at a psychiatric department between August 1, 2017 and December 31, 2019. Subjects' levels of D-dimer and SFMC were measured simultaneously. Plasma levels of D-dimer and SFMC were measured using NANOPIA® D-dimer and NANOPIA® SF. Subjects with positive D-dimer (≥1.0 µg/mL) results underwent contrast computed tomography for confirmation of VTE within 12 hours of D-dimer measurement. A receiver operating characteristic curve analysis was performed to examine the usefulness of SFMC for the diagnosis of VTE.<bold>Results: </bold>Only 109 of the 783 subjects without symptoms suggestive of VTE participated in the study. Out of 41 subjects with positive D-dimer results, 17 subjects were diagnosed with VTE. A receiver operating characteristic curve analysis was performed to determine cutoff values. The area under the curves was 0.848 for SFMC (p<0.001, 95% CI 0.722 to 0.974), and the optimal cutoff value was 10.0 µg/mL (sensitivity 58.8%, specificity 100%, positive predictive value 100%, negative predictive value 77.4%).<bold>Conclusion: </bold>SFMC was useful for diagnosing VTE in the psychiatric patients with positive D-dimer results.
- Publication
Vascular Health & Risk Management, 2021, Vol 17, p239
- ISSN
1176-6344
- Publication type
journal article
- DOI
10.2147/VHRM.S307689