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- Title
Redox Center Modification of Lapachones towards the Synthesis of Nitrogen Heterocycles as Selective Fluorescent Mitochondrial Imaging Probes.
- Authors
dos Santos, Fabíola S.; Dias, Gleiston G.; de Freitas, Rossimiriam P.; Santos, Lucas S.; de Lima, Guilherme F.; Duarte, Hélio A.; de Simone, Carlos A.; Rezende, Lidia M. S. L.; Vianna, Monique J. X.; Correa, José R.; Neto, Brenno A. D.; da Silva Júnior, Eufrânio N.
- Abstract
We describe herein a synthetic strategy for the synthesis of new fluorescent imidazole and phenazine derivatives synthesized from lapachol, a naturally occurring naphthoquinone isolated from Tabebuia species (ipê tree). The photophysical properties and computational details of these compounds have been studied, aiming at gaining a complete understanding of the potential of these derivatives as probes capable of staining mitochondria selectively. Cell imaging experiments proved the capacity of the imidazole derivatives as selective fluorescent mitochondrial imaging probes. These heterocycles present the same staining patterns as MitoTracker Red, corroborating the potential of these compounds as new mitochondria markers permeable to the cell membrane.
- Subjects
HETEROCYCLIC compounds synthesis; OXIDATION-reduction reaction; FLUORESCENCE; IMIDAZOLES; NAPHTHOQUINONE
- Publication
European Journal of Organic Chemistry, 2017, Vol 2017, Issue 26, p3763
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201700227