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- Title
Incidence and Severity of Lymphoedema following Limb Salvage of Extremity Soft Tissue Sarcoma.
- Authors
Friedmann, Daniel; Wunder, Jay S.; Ferguson, Peter; Sullivan, Brian O.; Roberge, David; Catton, Charles; Freeman, Carolyn; Saran, Neil; Turcotte, Robert E.
- Abstract
Background and Purpose. Lymphoedema is a serious complication following limb salvage for extremity soft tissue sarcomas (STSs) for which little is known. We aimed to evaluate its incidence, its, severity and its associated risk factors. Material and Method. Patient and tumor characteristics, treatment modalities and complications and functional outcomes (MSTS 1987, TESS), and lymphoedema severity (Stern) were all collected from prospective databases. Charts were retrospectively abstracted for BMI and comorbidities. Results. There were 289 patients (158 males). Mean age was 53 (16-88). Followup ranged between 12 and 60months with an average of 35 and a median of 36 months. Mean BMI was 27.4 (15.8-52.1). 72% had lower extremity tumors and 38% upper extremity. Mean tumor size was 8.1 cm (1.0-35.6 cm). 27% had no adjuvant radiation, 62% had 50Gy, and 11% received 66Gy. The incidence of lymphoedema was 28.8% (206 none, 58 mild, 22 moderate, 3 severe, and 0 very severe).Mean MSTS score was 32 (11-35) and TESS was 89.4 (32.4-100). Radiation dose was significantly correlated with tumor size > 5 cm (P = 0.0001) and TESS score (P = 0.001), but not MSTS score (P = 0.090). Only tumor size > 5 cm and depth were found to be independent predictors of significant lymphoedema. Conclusion. Nine percent of STS patients in our cohort developed significant (grade > 2) lymphoedema. Tumor size > 5 cm and deep tumors were associated with an increased occurrence of lymphoedema but not radiation dosage.
- Publication
Sarcoma, 2011, p1
- ISSN
1357-714X
- Publication type
Journal Article
- DOI
2011/289673