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- Title
EBV-Associated Smooth Muscle Neoplasms: Solid Tumors Arising in the Presence of Immunosuppression and Autoimmune Diseases.
- Authors
Dalal, Kimberly Moore; Antonescu, Cristina R.; DeMatteo, Ronald P.; Maki, Robert G.
- Abstract
Background. Epstein-Barr virus (EBV)-related smooth muscle neoplasms (SMNs) have been associated with immune dysregulation, most notably in patients who have undergone solid organ transplantation or in patients with HIV/AIDS. Objective. to report our experience with EBV-related neoplasms as well as describing the first EBV-related SMN in the setting of administration of glucocorticoids and the tumor necrosis factor inhibitor etanercept. Design. We have case reports, of minimum 3-year follow-up, 2002-2005. Setting. It was held in an academic and tertiary referral cancer center. Patients. Patients are with dysregulated immunity after solid organ transplantation, HIV/AIDS, or with psoriasis after treatment with etanercept. Interventions. There were discontinuation of etanercept, right hepatic trisegmentectomy, and chemotherapy.Measurements.We use survival as a measurement here. Results. Patients who were able to withstand reduction in immunosuppression survived. Surgical resection or chemotherapy was successful in delaying progression of disease. Limitations. There was a relatively short follow-up for these slow-growing neoplasms. Conclusion. EBV-related SMNs have variable aggressiveness.While chemotherapymay slow disease progression, resection and improving the host immune status provide the best opportunity for primary tumor control.
- Subjects
EPSTEIN-Barr virus; SMOOTH muscle tumors; GLUCOCORTICOIDS; IMMUNOSUPPRESSION; AUTOIMMUNE diseases; TRANSPLANTATION of organs, tissues, etc.; IMMUNITY
- Publication
Sarcoma, 2008, p1
- ISSN
1357-714X
- Publication type
Article
- DOI
10.1155/2008/859407