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- Title
Clinical features, disease progression, and use of healthcare resources in a large sample of 866 patients from 24 headache centers: A real‐life perspective from the Italian chROnic migraiNe (IRON) project.
- Authors
Barbanti, Piero; Fofi, Luisa; Grazzi, Licia; Vernieri, Fabrizio; Camarda, Cecilia; Torelli, Paola; Cevoli, Sabina; Russo, Antonio; Bono, Francesco; Finocchi, Cinzia; Rao, Renata; Messina, Stefano; De Simone, Roberto; Vanacore, Nicola; Bonassi, Stefano; Egeo, Gabriella; Aurilia, Cinzia; D'Amico, Domenico; Altamura, Claudia; Quintana, Simone
- Abstract
Objective: To develop a dedicated Italian chronic migraine (CM) database (IRON project) to overcome disease misconceptions, improve clinical administration, reduce patients' burden, and rationalize economic resource allotment. Background: Proper CM management requires a comprehensive appraisal of its full clinical, social, and economic complexity. Methods: In this cross‐sectional study, CM patients were screened in 24 certified headache centers with face‐to‐face interviews. Information on sociodemographic factors, medical history, characteristics of CM, and of prior episodic migraine (EM), and healthcare resource use was gathered using a semistructured web‐based questionnaire. Results: A total of 866 CM patients were enrolled. CM started ~20 years after EM onset (age at EM onset 17.4 ± 9.1 vs. age at CM onset 35.3 ± 12.5 [mean ± SD]). CM prophylaxis, used by 430/866 (49.6%) of the patients, was often ineffective, not tolerated, and prematurely discontinued. Medications and diagnostic workup, frequently inappropriate, were mostly subsidized by the Italian national health service. CM patients with ≥25 headache days/month revealed substantial clinical differences and heavier disability and economic burden compared with those with <25 headache days/month. Conclusions: CM is a heterogeneous headache disorder deserving more in‐depth clinical characterization, sharper diagnostic criteria, and tailored treatments. CM registries are expected to improve clinical management, resulting in increased disease awareness, better healthcare resource allocation, and reduced economic burden.
- Subjects
ITALY; DISEASE progression; MIGRAINE; CHRONIC diseases; BIBLIOGRAPHIC databases; DATABASE design; CROSS-sectional method; INTERVIEWING; MEDICAL care use; ATTITUDES toward illness; SOCIOECONOMIC factors; HEALTH literacy; HEALTH; QUESTIONNAIRES; DESCRIPTIVE statistics; ECONOMIC aspects of diseases; SYMPTOMS
- Publication
Headache: The Journal of Head & Face Pain, 2021, Vol 61, Issue 6, p936
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/head.14123