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- Title
Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing.
- Authors
Naccache, Samia N.; Peggs, Karl S.; Mattes, Frank M.; Phadke, Rahul; Garson, Jeremy A.; Grant, Paul; Samayoa, Erik; Federman, Scot; Miller, Steve; Lunn, Michael P.; Gant, Vanya; Chiu, Charles Y.
- Abstract
Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade.
- Subjects
TREATMENT of encephalitis; VIRAL disease diagnosis; DIAGNOSIS of deafness; DISEASE complications; IMMUNOCOMPROMISED patients; METAGENOMICS; DISEASE progression
- Publication
Clinical Infectious Diseases, 2015, Vol 60, Issue 6, p919
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciu912