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- Title
Impact of Inosine Triphosphatase Gene Variants on the Risk of Anemia in HIV/Hepatitis C Virus-Coinfected Patients Treated for Chronic Hepatitis C.
- Authors
Rallón, Norma I.; Morello, Judit; Labarga, Pablo; Benito, José M.; Rodríguez-Nóvoa, Sonia; Vispo, Eugenia; Barreiro, Pablo; Castro, M.Á ngeles; Aguirrebengoa, Koldo; Pineda, Juan A.; Miralles, P.; Tellez, M. Jesús; Portu, Joaquín; Miralles, Celia; Ocampo, Antonio; Soriano, Vincent
- Abstract
The article reports on the role of rs1127354/rs7270101 alleles at the inosine triphosphatase gene on ribavirin-induced anemia. This clinical condition has been assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection. It states that anemia developed in 80 percent of the patients with normal ITPA activity as compared to 33 percent of the patients with reduced ITPA activity. A table containing information on pharmacogenetic substudy on patients is presented.
- Subjects
ALLELES; ENZYMES; RIBAVIRIN; ANEMIA; HEPATITIS C virus; HIV infections; CHARTS, diagrams, etc.; PHARMACOGENOMICS; GENETICS
- Publication
Clinical Infectious Diseases, 2011, Vol 53, Issue 12, p1291
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/cir665