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- Title
Detection of Nonnucleoside Reverse-Transcriptase Inhibitor—Resistant HIV-1 after Discontinuation of Virologically Suppressive Antiretroviral Therapy.
- Authors
Hare, C. Bradley; Mellors, John; Krambrink, Amy; Zhaohui Su; Skiest, Daniel; Margolis, David M.; Patel, Sheran S.; Barnas, Douglas; Frenkel, Lisa; Coombs, Robert W.; Aweeka, Francesca; Morse, Gene D.; Haas, David W.; Boltz, Valerie; Palmer, Sarah; Coffin, John; Havlir, Diane V.
- Abstract
Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reversetranscriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400 copies/mL and ⩽50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.
- Subjects
HIV; ANTIVIRAL agents; GENETIC mutation; MICROBIAL mutation; HIGHLY active antiretroviral therapy; DRUG resistance in microorganisms; EFFECT of drugs on microorganisms; VIRUSES; RNA
- Publication
Clinical Infectious Diseases, 2008, Vol 47, Issue 3, p421
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/589867