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- Title
No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis.
- Authors
Robertson, E.; Jones, I.; Middle, F.; Moray, J.; Craddock, N.
- Abstract
Robertson E, Jones I, Middle F, Moray J, Craddock N. No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis. Acta Psychiatr Scand 2003: 108: 387–391. © Blackwell Munksgaard 2003. To examine whether variation at two common polymorphisms, T102C and −1438AG, of the serotonin 2A gene ( 5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth (the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.
- Subjects
POSTPARTUM psychoses; PERINATAL mood &; anxiety disorders; GENETICS; POSTPARTUM depression
- Publication
Acta Psychiatrica Scandinavica, 2003, Vol 108, Issue 5, p387
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1034/j.1600-0447.2003.00167.x