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- Title
Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.
- Authors
Gileadi, Opher
- Abstract
Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention.
- Subjects
GUANYLATE cyclase regulation; MOLECULAR structure of enzymes; DRUG development; ANGINA pectoris treatment; PULMONARY hypertension treatment
- Publication
Biochemical Society Transactions, 2014, Vol 42, Issue 1, p108
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20130228