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- Title
The importance of P and type 1 fimbriae for the persistence of Escherichia coli in the human gut.
- Authors
Tullus, K.; Kühn, I.; Ørskov, I.; Ørskov, F.; Möllby, R.
- Abstract
The faecal Escherichia coli flora was studied in 89 infants. Each infant was followed with a mean of 12 faecal samples (range 5–21) between 0 and 18 months of age. All isolates were assayed for P fimbriae and biochemically phenotyped and the persistence of each strain (phenotype) in the infant's gut was determined. In a subset of strains the occurrence of type 1 fimbriae and adherence to HeLa cells was studied. Thirty-one per cent of isolates belonging to strains colonizing for longer than 6 months expressed P fimbriae compared to 19% of the isolates from strains colonizing 1–6 months or transient strains colonizing less than 1 month. Type 1 fimbriae and adherence to HeLa cells occurred similarly often in all groups of strains. We conclude that P fimbriae, but not type 1 fimbriae or HeLa cell adherence seemed to contribute to the ability of the E. coli strain to colonize the human intestine.
- Publication
Epidemiology & Infection, 1992, Vol 108, Issue 3, p415
- ISSN
0950-2688
- Publication type
Article
- DOI
10.1017/S095026880004992X