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- Title
Ocena zmienności przesączania kłębuszkowego (eGFR) u dzieci po przeszczepieniu komórek hematopoetycznych w 12 miesięcznym okresie obserwacji.
- Authors
ZACHWIEJA, Katarzyna; KOROHODA, Przemysław; KRASOWSKA-KWIECIEŃ, Aleksandra; KWINTA-RYBICKA, Joanna; MIKLASZEWSKA, Monika; MOCZULSKA, Anna; GOŹDZIK, Jolanta; DROŻDŻ, Dorota
- Abstract
Introduction: Hematopoietic stem cell transplantation (HSCT) is performed more often nowadays in various oncologic and other diseases. The renal function assessment is obligatory for safe treatment. The aim of the study was the variability evaluation of eGFR in 40 children of median age: 8.6 yrs treated with HSCT (in 11 autologous and in 29 allogenic) in one year period. The eGFR assessment was done before, one week, one month, 6 and 12 months after HSCT based on following equations: cystatin C - eGFR (cystC); Schwartz bed-side - eGFR (BS) and Schwartz trimarker - eGFR (3M) corrected for eGFR >60 ml/min/1.73 m2 and with creatinine clearance - eGFR (U24h). The Iohexol diseaperance method eGFR(IOH), regarding as reference method was performed before, 6 and 12 months after HSCT. Results: (all eGFR values are in ml/min/1.73 m2) The mean value of eGFR (IOH) was in normal range before: (131.8 ± 35.7) and in 6 months (104.2 ± 45.6; p=0.024 to eGFR before) and in 12 months after HSCT (109.6 ± 33.0; p=0.052). One year after HSCT eGFR values were lower with statistical significance according to all but one equation (eGFR-U24h) with mean difference from 14.2 to 31.2. One week after HSCT increase of eGFR was observed with mean difference from 15.9 to 27.9. 1 month post HSCT eGFR decreased of mean difference from 6.4 to 31.8; then in 6 months from 16.4 to 27.9. One year later eGFR was higher compared to 6 months eGFR with mean difference from 6.4 to 31.2. The highest variability of GFR was seen during first 1 month after procedure. In 25% if children eGFR was <90 ml/ min/1.73 m2 one year after HSCT. The eGFR (3M) showed the best concordance with eGFR(IOH), the lowest agreement was noted for eGFR (U24h). Conclusions: The renal function in 12 months after HSCT is well preserved with non clinically significant decrease in eGFR. The temporary deterioration of eGFR was confirmed in 1 month up to 6 months after with improvement tendency of eGFR in 1 year observation. The best precision of eGFR calculation in this group of children is obtained with trimarker formula.
- Publication
Review of Medicine / Przeglad Lekarski, 2019, Vol 76, Issue 5, p241
- ISSN
0033-2240
- Publication type
Article