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- Title
Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers.
- Authors
Yangqing Chen; Yong Liu; Xiaodan Shen; Zhimin Chang; Longhua Tang; Wen-Fei Dong; Mingyu Li; Jian-Jun He
- Abstract
We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing.
- Subjects
IMPRINTED polymers; TESTOSTERONE; SILICON-on-insulator technology; ETHYLENE glycol; POLYMERIZATION; BIOSENSORS; SENSITIVITY analysis
- Publication
Sensors (14248220), 2015, Vol 15, Issue 12, p31558
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s151229877