We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Campylobacter pylori-Associated Gastritis and Immune Response in a Population at Increased Risk of Gastric Carcinoma.
- Authors
Fox, James G.; Correa, Pelayo; Taylor, Nancy S.; Zavala, Diego; Fontham, Elizabeth; Janney, Frances; Rodriguez, Elsie; Hunter, Fred; Diavolitsis, Stavros
- Abstract
A series of 169 consecutive patients from low socio-economic strata attending the gastroenterology clinic of Charity Hospital in New Orleans were evaluated clinically and endoscopically. This general New Orleans population is known to he at increased risk of developing gastric carcinoma. The type of gastritis was identified histologically, and the presence of Campylobacter pylori was determined by culture and/or histology. The overall prevalence of C. pylori infection in this patient population was 11% (126/169). These findings were correlated with serum IgG antibody to C. pylori using an ELISA. Fifteen patients with neither demonstrable gastritis nor C. pylori served as negative controls and had low levels of IgG antibody to C pylori. A strong correlation was found between Campylobacter detection by morphologic and/or culture technique and the presence of serum IgG antibody. For all patients examined, the sensitivity of the ELISA was 94.2% and the specificity 75.5%. The highest ELISA values for IgG anti-body (sensitivity = 89%, specificity = 75%) were detected in patients positive for C. pylori., who also had diffuse antral gastritis with prominent lymphoid follicles. For patients with chronic atrophic gastritis and intestinal metaplasia, the sensitivity of the ELISA was 96% and the specificity 67%. The latter number may indicate underrepresentation of foveolar epithelium in biopsies with extreme intestinal metaplasia. Results suggest a high prevalence of chronic infection of C. pylori in this clinic population. The possible role of C. pylori in the development of precursor lesions of gastric cancer is discussed.
- Subjects
GASTRITIS; GASTROENTERITIS; HELICOBACTER pylori; STOMACH cancer; GASTROENTEROLOGY; PATHOLOGY; IMMUNE response
- Publication
American Journal of Gastroenterology (Springer Nature), 1989, Vol 84, Issue 7, p775
- ISSN
0002-9270
- Publication type
Article