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- Title
Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease.
- Authors
Li, Xianghui; Jiang, Kaixin; Ruan, Yantian; Zhao, Siyuan; Zhao, Yiming; He, Yuhua; Wang, Zhili; Wei, Jiacun; Li, Qiming; Yang, Changyong; Li, Yanzhang; Teng, Tieshan
- Abstract
Hydrogen sulfide (H2S) has emerged as the third "gasotransmitters" and has a crucial function in the diversity of physiological functions in mammals. In particular, H2S is considered indispensable in preventing the development of liver inflammation in the case of excessive caloric ingestion. Note that the concentration of endogenous H2S was usually low, making it difficult to discern the precise biological functions. Therefore, exogenous delivery of H2S is conducive to probe the physiological and pathological roles of this gas in cellular and animal studies. In this review, the production and metabolic pathways of H2S in vivo, the types of donors currently used for H2S release, and study evidence of H2S improvement effects on nonalcoholic fatty liver disease are systematically introduced.
- Subjects
NON-alcoholic fatty liver disease; HYDROGEN sulfide; HEPATITIS
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 20, p12202
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232012202