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- Title
Platelets Are Critical Key Players in Sepsis.
- Authors
Vardon-Bounes, Fanny; Ruiz, Stéphanie; Gratacap, Marie-Pierre; Garcia, Cédric; Payrastre, Bernard; Minville, Vincent
- Abstract
Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet–pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed.
- Subjects
IMMUNE response; BLOOD coagulation; SEPSIS
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 14, p3494
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20143494