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- Title
Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy.
- Authors
Cofano, Fabio; Boido, Marina; Monticelli, Matteo; Zenga, Francesco; Ducati, Alessandro; Vercelli, Alessandro; Garbossa, Diego
- Abstract
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial phase in the pathophysiological process of SCI concerns the well-known secondary injury, which is the uncontrolled and destructive cascade occurring later with aberrant molecular signaling, inflammation, vascular changes, and secondary cellular dysfunctions. The use of mesenchymal stem cells (MSCs) represents one of the most important and promising tested strategies. Their appeal, among the other sources and types of stem cells, increased because of their ease of isolation/preservation and their properties. Nevertheless, encouraging promise from preclinical studies was followed by weak and conflicting results in clinical trials. In this review, the therapeutic role of MSCs is discussed, together with their properties, application, limitations, and future perspectives.
- Subjects
SPINAL cord injuries; CELLULAR therapy; MESENCHYMAL stem cells; STEM cells
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 11, p2698
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20112698