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- Title
Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica.
- Authors
Park, Sang Hee; Choi, Eunju; Kim, Sunggyu; Kim, Dong Sam; Kim, Ji Hyeon; Chang, SeokGu; Choi, Jae Seok; Park, Kyung Ja; Roh, Kyung-Baeg; Lee, Jongsung; Yoo, Byong Chul; Cho, Jae Youl
- Abstract
Loliolide is a monoterpenoid hydroxylactone found in many algae, including fresh water green algae, Prasiola japonica. To date, loliolide and compounds in P. japonica have not been studied systematically with respect to skin pharmacology. In this study, we investigated oxidative stress-protective and anti-melanogenic effects of loliolide and P. japonica ethanol extract (Pj-EE), known to contain loliolide, in human keratinocyte (HaCaT) cells and mouse melanoma (B16F10) cells. Loliolide suppressed the transcription of genes encoding matrix metalloproteinases (MMPS), which were induced in HaCaT cells by hydrogen peroxide (H2O2) treatment. Loliolide and Pj-EE not only reduced the melanin secretion and content in B16F10 cells but also increased the expression of the antioxidant proteins nuclear factor (erythroid-derived 2)-like 2 (NRF2) and heme oxygenase-1 (HO-1) in HaCaT cells subjected to H2O2 treatment. Furthermore, loliolide and Pj-EE decreased expression of the anti-melanogenic protein microphthalmia-associated transcription factor (MITF) and tyrosinase in B16F10 cells subjected to α-melanocyte-stimulating hormone (α-MSH) treatment. Our findings demonstrate that loliolide and Pj-EE have antioxidant and anti-melanogenic effects on skin.
- Subjects
OXIDATIVE stress; MELANOGENESIS; GREEN algae; FRESH water; KERATINOCYTES
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 9, p2825
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19092825