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- Title
The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response?
- Authors
de Ramon, Laura; Guiteras, Jordi; Guiteras, Roser; Cruzado, Josep M.; Grinyó, Josep M.; Torras, Juan
- Abstract
Costimulatory molecules have been identified as crucial regulators in the inflammatory response in various immunologic disease models. These molecules are classified into four different families depending on their structure. Here, we will focus on various ischemia studies that use costimulatory molecules as a target to reduce the inherent inflammatory status. Furthermore, we will discuss the relevant role of T regulatory cells in these inflammatory mechanisms and the costimulatory pathways in which they are involved.
- Subjects
ISCHEMIA; BLOOD flow; INFLAMMATION; MOLECULES; T cells
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 5, p1283
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19051283